Profilers

The available profilers in Toolbox are separated into six categories based on the information they provide:

• Predefined – Predefined categories are set of rules for grouping chemicals developed by recognized institutions or organizations and they could be considered as “standard” categorization schemes (e.g. US-EPA New Chemical categories);
• General mechanistic – Mechanistic categorization schemes consist of rules for identification of important general chemical characteristics based on published or expert knowledge (e.g. DNA binding by OASIS)
• Endpoint specific – Mechanistic categorization schemes consist of rules for identification of chemical characteristics associated with a specific endpoint based on published or expert knowledge (e.g. DNA alerts for AMES, CA and MNT by OASIS)
• Empiric – Empiric categorization schemes include rules used to determine the chemical elements constituting the target chemical, its chemical functionality and structural similarity (e.g. Organic functional groups)
• Toxicological – The toxicological category includes only one profiler. The profiler contains boundaries based on repeated dose toxicity test data extracted from database of Hazard Evaluation Support System (HESS).
• Custom – schemes based on the user`s knowledge. Example Prioritization Scheme (PBT) identifying the persistence, bioaccumulation and toxicity of the target chemical(s) based on their experimental and/or predicted data is included as a custom profiler.